Les publications

Les publicationsThématique 1

Biologie vasculaire et du globule rouge (BVGR)

1- Aufradet E, Douillard A, Charrin E, Romdhani A, De Souza G, Bessaad A, Faes C, Bourgeaux V, Chirico EN, Canet-Soulas E, Pialoux V, Martin C. Physical activity limits pulmonary endothelial activation in sickle cell SAD mice. Blood 123: 2745-2747, 2014.

2- Debevec T, Pialoux V, Mekjavic IB, Eiken O, Mury P, Millet GP. Moderate exercise blunts oxidative stress induced by normobaric hypoxic confinement. Medicine and science in sports and exercise 46: 33-41, 2014.

3- Faes C, Balayssac-Siransy E, Connes P, Hivert L, Danho C, Bogui P, Martin C, Pialoux V. Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation. British journal of haematology 164: 124-130, 2014.

4- Joly P, Pondarre C, Badens C. [Beta-thalassemias: molecular, epidemiological, diagnostical and clinical aspects]. Annales de biologie clinique 72: 639-668, 2014.

5- Saboul D, Pialoux V, Hautier C. The breathing effect of the LF/HF ratio in the heart rate variability measurements of athletes. European journal of sport science 14 Suppl 1: S282-288, 2014.

6- Ballas SK, Connes P. The paradox of the serrated sickle erythrocyte: The importance of the red blood cell membrane topography. Clin Hemorheol Microcirc 63: 149-152, 2015.

7- Charlot K, Moeckesch B, Jumet S, Romana M, Waltz X, Divialle-Doumdo L, Hardy-Dessources MD, Petras M, Tressieres B, Pichon A, Tarer V, Hue O, Etienne-Julan M, Antoine-Jonville S, Connes P. Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study. Pediatr Blood Cancer 62: 1962-1967, 2015.

8- Charrin E, Aufradet E, Douillard A, Romdhani A, Souza GD, Bessaad A, Faes C, Chirico EN, Pialoux V, Martin C. Oxidative stress is decreased in physically active sickle cell SAD mice. British journal of haematology 168: 747-756, 2015.


9- Connes P. Obstructive sleep apnea and sickle cell disease: Towards hemorheological abnormalities and vascular dysfunction worsening. Sleep Med Rev 24C: 101-102, 2015.


10- Connes P. Sickle cell trait, exertional rhabdomyolysis, and compartment syndrome. Lancet 385: 1948, 2015.


11- Lobo CL, do Nascimento EM, Abelha R, Queiroz AM, Connes P, Cardoso GP, Ballas SK. Risk Factors of Pulmonary Hypertension in Brazilian Patients with Sickle Cell Anemia. PLoS One 10: e0137539, 2015.


12- Debevec T, Pialoux V, Saugy J, Schmitt L, Cejuela R, Mury P, Ehrstrom S, Faiss R, Millet GP. Prooxidant/Antioxidant Balance in Hypoxia: A Cross-Over Study on Normobaric vs. Hypobaric "Live High-Train Low". PloS one 10: e0137957, 2015.


13- Diaw M, Pialoux V, Martin C, Samb A, Diop S, Faes C, Mury P, Sall Diop N, Diop SN, Ranque B, Mbaye MN, Key NS, Connes P. Sickle Cell Trait Worsens Oxidative Stress, Abnormal Blood Rheology, and Vascular Dysfunction in Type 2 Diabetes. Diabetes Care 38: 2120-2127, 2015.


14- Faes C, Charrin E, Connes P, Pialoux V, Martin C. Chronic physical activity limits blood rheology alterations in transgenic SAD mice. American journal of hematology 90: E32-33, 2015.


15- Ferdinand S, Connes P, Brudey L, Cita KC, Tressieres B, Lemonne N, Hardy-Dessources MD, Lamarre Y, Waltz X, Etienne-Julan M, Romana M. Impact of eNOS polymorphisms on red blood cell aggregation in sickle cell disease. Blood Cells Mol Dis 55: 151-153, 2015.


16- Grau M, Mozar A, Charlot K, Lamarre Y, Weyel L, Suhr F, Collins B, Jumet S, Hardy-Dessources MD, Romana M, Lemonne N, Etienne-Julan M, Antoine-Jonville S, Bloch W, Connes P. High red blood cell nitric oxide synthase activation is not associated with improved vascular function and red blood cell deformability in sickle cell anaemia. Br J Haematol 168: 728-736, 2015.


17- Joly P, Guillaud O, Hervieu V, Francina A, Mornex JF, Chapuis-Cellier C. Clinical heterogeneity and potential high pathogenicity of the Mmalton Alpha 1 antitrypsin allele at the homozygous, compound heterozygous and heterozygous states. Orphanet journal of rare diseases 10: 130, 2015.


18- Key NS, Connes P, Derebail VK. Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory. Br J Haematol 170: 5-14, 2015.


19- Lemonne N, Charlot K, Waltz X, Ballas SK, Lamarre Y, Lee K, Hierso R, Connes C, Etienne-Julan M, Romana M, Connes P. Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia. Haematologica 100: e383-386, 2015.


20- Mozar A, Charlot K, Sandor B, Rabai M, Lemonne N, Billaud M, Hardy-Dessources MD, Beltan E, Pandey RC, Connes P*, Ballas SK*. Pfaffia paniculata extract improves red blood cell deformability in sickle cell patients. Clin Hemorheol Microcirc 62: 327-333, 2015. (*equivalent position)



21- Prieur F, Pialoux V, Mestas JL, Mury P, Skinner S, Lafon C. Evaluation of inertial cavitation activity in tissue through measurement of oxidative stress. Ultrasonics sonochemistry 26: 193-199, 2015.


22- Ravelojaona M, Feasson L, Oyono-Enguelle S, Vincent L, Djoubairou B, Ewa'Sama Essoue C, Messonnier LA. Evidence for a profound remodeling of skeletal muscle and its microvasculature in sickle cell anemia. The American journal of pathology 185: 1448-1456, 2015.


23- Charrin E, Ofori-Acquah SF, Nader E, Skinner S, Connes P, Pialoux V, Joly P, Martin C. Inflammatory and oxidative stress phenotypes in transgenic sickle cell mice. Blood Cells Mol Dis 62: 13-21, 2016.


24- Charlot K, Romana M, Moeckesch B, Jumet S, Waltz X, Divialle-Doumdo L, Hardy-Dessources MD, Petras M, Tressieres B, Tarer V, Hue O, Etienne-Julan M, Antoine-Jonville S, Connes P. Which side of the balance determines the frequency of vaso-occlusive crises in children with sickle cell anemia: Blood viscosity or microvascular dysfunction? Blood Cells Mol Dis 56: 41-45, 2016.


25- Chirico EN, Faes C, Connes P, Canet-Soulas E, Martin C, Pialoux V. Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease. Sports Med 46: 629-639, 2016.


26- Chirico EN, Di Cataldo V, Chauveau F, Geloen A, Patsouris D, Theze B, Martin C, Vidal H, Rieusset J, Pialoux V and Canet-Soulas E. Magnetic resonance imaging biomarkers of exercise-induced improvement of oxidative stress and inflammation in the brain of old high-fat-fed ApoE-/- mice. J Physiol. 2016;594:6969-6985.


27- Cita KC, Ferdinand S, Connes P, Brudey L, Tressieres B, Etienne-Julan M, Lemonne N, Tarer V, Elion J, Romana M. Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia. Blood Cells Mol Dis 58: 21-25, 2016.


28- Cita KC, Brureau L, Lemonne N, Billaud M, Connes P, Ferdinand S, Tressieres B, Tarer V, Etienne-Julan M, Blanchet P, Elion J, Romana M. Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength. PLoS One 11: e0154866, 2016.


29- Connes P, Alexy T, Detterich J, Romana M, Hardy-Dessources MD, Ballas SK. The role of blood rheology in sickle cell disease. Blood Rev 30: 111-118, 2016.


30- Debevec T, Pialoux V, Ehrstrom S, Ribon A, Eiken O, Mekjavic IB, Millet GP. FemHab: The effects of bed rest and hypoxia on oxidative stress in healthy females. Journal of applied physiology jap 00919 02015, 2016.


31- Delacour H, Konopacki J, Plantamura J, Lacan P, Joly P. Hb Hope [beta136Gly-->Asp] and Hb Grady [alpha119_120insGluPheThr] compound heterozygosity in a Mauritanian patient. Clinical chemistry and laboratory medicine 54: e35-36, 2016.


32- Di Cataldo V, Geloen A, Langlois JB, Chauveau F, Theze B, Hubert V, Wiart M, Chirico EN, Rieusset J, Vidal H, Pialoux V and Canet-Soulas E. Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE-/- Mice. Front Physiol. 2016;7:453.


33- Friedenreich CM, Pialoux V, Wang Q, Shaw E, Brenner DR, Waltz X, Conroy S, Johnson R, Woolcott CG,. Poulin MJ, Courneya KS. Effects of Exercise on Markers of Oxidative Stress: An Ancillary Analysis of the Alberta Physical Activity and Breast Cancer Prevention Trial. BMJ Open Sport Exerc Med  2016;2:e000171


34- Gastebois C, Chanon S, Rome S, Durand C, Pelascini E, Jalabert A, Euthine V, Pialoux V, Blanc S, Simon C and Lefai E. Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance. Physiol Rep. 2016;4.


35- Jackson PA, Pialoux V, Corbett D, Drogos L, Erickson KI, Eskes GA and Poulin MJ. Promoting brain health through exercise and diet in older adults: a physiological perspective. J Physiol. 2016;594:4485-98.


36- Joly P, Garnier N, Kebaili K, Renoux C, Dony A, Cheikh N, Renard C, Ceraulo A, Cuzzubbo D, Pondarre C, Martin C, Pialoux V, Francina A, Bertrand Y, Connes P. G6PD deficiency and absence of alpha-thalassemia increase the risk for cerebral vasculopathy in children with sickle cell anemia. Eur J Haematol 96: 404-408, 2016.


37- Jiang Z, Luo HY, Huang S, Farrell JJ, Davis L, Theberge R, Benson KA, Riolueang S, Viprakasit V, Al-Allawi NA, Unal S, Gumruk F, Akar N, Basak AN, Osorio L, Badens C, Pissard S, Joly P, Campbell AD, Gallagher PG, Steinberg MH, Forget BG and Chui DH. The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) beta(0) -thalassaemia homozygotes. Br J Haematol. 2016;172:958-65.


38- Khalyfa A, Khalyfa AA, Akbarpour M, Connes P, Romana M, Lapping-Carr G, Zhang C, Andrade J and Gozal D. Extracellular microvesicle microRNAs in children with sickle cell anaemia with divergent clinical phenotypes. Br J Haematol. 2016;174:786-98.


39- Lemonne N, Billaud M, Waltz X, Romana M, Hierso R, Etienne-Julan M, Connes P. Rheology of red blood cells in patients with HbC disease. Clin Hemorheol Microcirc 61: 571-577, 2016.


40- Mozar A, Connes P, Collins B, Hardy-Dessources MD, Romana M, Lemonne N, Bloch W, Grau M. Red blood cell nitric oxide synthase modulates red blood cell deformability in sickle cell anemia. Clin Hemorheol Microcirc 64: 47-53, 2016.


41- Pichon AP, Connes P and Robach P. Effects of acute and chronic hematocrit modulations on blood viscosity in endurance athletes. Clin Hemorheol Microcirc. 2016;64:115-123.


42- Rabbind SinghA ; LacanP ; CadetE ; BignetP ; DumesnilC ; Vannier et al. , A New Intergenic ?-Globin Deletion (?-?(?125)) Found in a Kabyle Population., Hemoglobin, 2016, 40, 108-12


43- Renoux C, Parrow N, Faes C, Joly P, Hardeman M, Tisdale J, Levine M, Garnier N, Bertrand Y, Kebaili K, Cuzzubbo D, Cannas G, Martin C, Connes P. Importance of methodological standardization for the ektacytometric measures of red blood cell deformability in sickle cell anemia. Clin Hemorheol Microcirc. 2016;62(2):173-9.


44- Renoux C, Romana M, Joly P, Ferdinand S, Faes C, Lemonne N, Skinner S, Garnier N, Etienne-Julan M, Bertrand Y, Petras M, Cannas G, Divialle-Doumdo L, Nader E, Cuzzubbo D, Lamarre Y, Gauthier A, Waltz X, Kebaili K, Martin C, Hot A, Hardy-Dessources MD, Pialoux V, Connes P. Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study. PLoS One 11: e0158182, 2016.


45- Ribon A, Pialoux V, Saugy JJ, Rupp T, Faiss R, Debevec T and Millet GP. Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia. Respir Physiol Neurobiol. 2016;223:23-7.


46- Sandor B, Marin M, Lapoumeroulie C, Rabai M, Lefevre SD, Lemonne N, El Nemer W, Mozar A, Francais O, Le Pioufle B, Connes P*, Le Van Kim C*. Effects of Poloxamer 188 on red blood cell membrane properties in sickle cell anaemia. Br J Haematol 173: 145-149, 2016. (*equivalent position)


47- Simonnet C, Elanga N, Joly P, Vaz T, Nacher M. Genetic modulators of sickle cell disease in French Guiana markers of the slave trade. Am J Hum Biol. 2016;28:811-816


48- Singh AR, Lacan P, Cadet E, Bignet P, Dumesnil C, Vannier JP, Joly P, Rochette J. A New Intergenic alpha-Globin Deletion (alpha-alphaDelta125) Found in a Kabyle Population. Hemoglobin 40: 108-112, 2016


49- Cannas G, Poutrel S and Thomas X. Hydroxycarbamine: from an Old Drug Used in Malignant Hemopathies to a Current Standard in Sickle Cell Disease. Mediterr J Hematol Infect Dis. 2017;9:e2017015.


50- Charlot K, Hierso R, Lemonne N, Romana M, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M, Tarer V, Ferracci S, Hardy-Dessources MD, Connes P. Changes in autonomic nervous activity during vaso-occlusive crisis in patients with sickle cell anemia. Br J Haematol In press.


51- Charlot K, Antoine-Jonville S, Moeckesch B, Jumet S, Romana M, Waltz X, Divialle-Doumdo L, Hardy-Dessources MD, Petras M, Tressieres B, Tarer V, Hue O, Etienne-Julan M and Connes P. Cerebral and muscular microvascular oxygenations in children with sickle cell disease: influence of hematology, hemorheology and vasomotion. Blood Cells Mol Dis. In press.


52- Chatel B, Hourde C, Gondin J, Foure A, Le Fur Y, Vilmen C, Bernard M, Messonnier LA and Bendahan D. Impaired muscle force production and higher fatigability in a mouse model of sickle cell disease. Blood Cells Mol Dis. 2017;63:37-44.


53- Chatel B, Messonnier LA, Hourde C, Vilmen C, Bernard M and Bendahan D. Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice. J Appl Physiol (1985). 2017:jap 01099 2016.


54- Debevec T, Millet GP and Pialoux V. Hypoxia-Induced Oxidative Stress Modulation with Physical Activity. Front Physiol. 2017;8:84.


55- Hierso R, Lemonne N, Villaescusa R, Lalanne-Mistrih ML, Charlot K, Etienne-Julan M, Tressieres B, Lamarre Y, Tarer V, Garnier Y, Hernandez AA, Ferracci S, Connes P, Romana M and Hardy-Dessources MD. Exacerbation of oxidative stress during sickle vaso-occlusive crisis is associated with decreased anti-band 3 autoantibodies rate and increased red blood cell-derived microparticle level: a prospective study. Br J Haematol. 2017;176:805-813.


56- Joly P, Renoux C, Lacan P, Bertrand Y, Cannas G, Garnier N, Cuzzubbo D, Kebaili K, Renard C, Gauthier A, Pialoux V, Martin C, Romana M and Connes P. UGT1A1 (TA)n genotype is not the major risk factor of cholelithiasis in sickle cell disease children. Eur J Haematol. 2017;98:296-301.


57- Orvain C, Joly P, Pissard S, Badiou S, Badens C, Bonello-Palot N, Couque N, Gulbis B and Aguilar-Martinez P. Diagnostic approach to hemoglobins with high oxygen affinity: experience from France and Belgium and review of the literature. Ann Biol Clin (Paris). 2017;75:39-51.


58- Le Moal E, Pialoux V, Juban G, Groussard C, Zouhal H, Chazaud B and Mounier R. Redox Control of Skeletal Muscle Regeneration. Antioxid Redox Signal. 2017.


59- Martin C, Pialoux V, Faes C, Charrin E, Connes P. Does physical activity increase or decrease the risk of sickle cell disease complications? Br J Sports Med In press.


60- Millet GP, Debevec T, Brocherie F, Girard O, Pialoux V. Commentaries on Viewpoint: Human skeletal muscle wasting in hypoxia: a matter of hypoxic dose? J Appl Physiol (1985). 2017;122:409-411.


61- Moeckesch B, Charlot K, Jumet S, Romana M, Divialle-Doumdo L, Hardy-Dessources MD, Petras M, Tressieres B, Tarer V, Hue O, Etienne-Julan M, Connes P* and Antoine-Jonville S*. Micro- and macrovascular function in children with sickle cell anemia and sickle cell haemoglobin C disease. Blood Cells Mol Dis. In press. (*equivalent position)


62- Moeckesch B, Connes P, Charlot K, Skinner S, Hardy-Dessources MD, Romana M, Jumet S, Petras M, Divialle-Doumdo L, Martin C, Tressieres B, Tarer V, Hue O, Etienne-Julan M, Antoine-Jonville S and Pialoux V. Association between oxidative stress and vascular reactivity in children with sickle cell anaemia and sickle haemoglobin C disease Br J Haematol. In press.


63- Pialoux V., Poulin MJ, Hemmelgarn BR, Muruve DP, Chirico EN, Faes C, Sola DY, Ahmed SB. Cyclooxygenase-2 inhibition prevents angiotensin II-induced oxidative stress in humans. Front Phyiol. 2017. In Press


64- Renoux C, Connes P, Nader E, Skinner S, Faes C, Petras M, Bertrand Y, Garnier N, Cuzzubbo D, Divialle-Doumdo L, Kebaili K, Renard C, Gauthier A, Etienne-Julan M, Cannas G, Martin C, Hardy-Dessources MD, Pialoux V, Romana M and Joly P. Alpha-thalassaemia promotes frequent vaso-occlusive crises in children with sickle cell anaemia through haemorheological changes. Ped Blood Cancer. In press.


65- Sornjai W, Lithanatudom P, Erales J, Joly P, Francina A, Hacot S, Fucharoen S, Svasti S, Diaz JJ, Mertani HC and Smith DR. Hypermethylation of 28S ribosomal RNA in beta-thalassemia trait carriers. Int J Biol Macromol. 2017;94:728-734.