Les publications

Les publicationsThématique 1

Biologie vasculaire et du globule rouge (BVGR)


  1. Beral L, Romana M, Lemonne N, David T, Connes P. Terminologies regarding sickle cell retinopathy and maculopathy. Clin Hemorheol Microcirc. 71(1): p. 1-2, 2019.
  2. Hequet O, Poutrel S, Connes P, Revesz D, Chelghoum Y, Kebaili K, Cannas G, Gauthier A, Guironnet-Paquet A, Vocanson M, Nicolas JF, Renoux C, Raba M, Cognasse F, Bertrand Y, Hot A, Joly P. Automatic depletion with Spectra Optia allows a safe 16% reduction of red blood cell pack consumption in exchanged sickle cell anemia patients. Transfusion. 10.1111/trf.15188, 2019.
  3. Mury P, Mura M, Della-Schiava N, Chanon S, Vieille-Marchiset A, Nicaise V, Chirico EN, Collet-Benzaquen D, Lermusiaux P, Connes P, Millon A, Pialoux V. Association between physical activity and sedentary behaviour on carotid atherosclerotic plaques: an epidemiological and histological study in 90 asymptomatic patients. Br J Sports Med. 10.1136/bjsports-2018-099677, 2019.
  4. Skinner S, Connes P, Sigaudo-Roussel D, Lo M, Liu KL, Nader E, Josset-Lamaugarny A, Charrin E, Martin C, Romanet-Faes C, Diaw M, Pialoux V, Fromy B. Altered blood rheology and impaired pressure-induced cutaneous vasodilation in a mouse model of combined type 2 diabetes and sickle cell trait. Microvasc Res. 122: p. 111-116, 2019.
  5. Skinner S, Diaw M, Ndour Mbaye M, Joly P, Renoux C, Masson C, Cuerq C, Lopez P, Ndour M, Diedhiou D, Sow D, Diop S, Samb A, Pialoux V, Connes P. Evaluation of agreement between hemoglobin A1c, fasting glucose, and fructosamine in Senegalese individuals with and without sickle-cell trait. PLoS One. 14(2): p. e0212552, 2019.



  1. Ballas SK, Connes P. Rheological properties of sickle erythrocytes in patients with sickle-cell anemia: The effect of hydroxyurea, fetal hemoglobin, and alpha-thalassemia. Eur J Haematol. 101(6): p. 798-803, 2018.
  2. Beral L, Lemonne N, Romana M, Charlot K, Billaud M, Acomat M, Zorobabel C, Nader E, Etienne-Julan M, David T, Connes P. Proliferative retinopathy and maculopathy are two independent conditions in sickle cell disease: Is there a role of blood rheology?1. Clin Hemorheol Microcirc. 10.3233/ch-180412, 2018.
  3. Charrin E, Dube JJ, Connes P, Pialoux V, Ghosh S, Faes C, Ofori-Acquah SF, Martin C. Moderate exercise training decreases inflammation in transgenic sickle cell mice. Blood Cells Mol Dis. 69: p. 45-52, 2018.
  4. Connes P. Special issue on sickle cell disease: Old and new concepts. Clin Hemorheol Microcirc. 68(2-3): p. 103-104, 2018.
  5. Connes P, Renoux C, Romana M, Abkarian M, Joly P, Martin C, Hardy-Dessources MD, Ballas SK. Blood rheological abnormalities in sickle cell anemia. Clin Hemorheol Microcirc. 68(2-3): p. 165-172, 2018.
  6. Delrieu L, Perol O, Fervers B, Friedenreich C, Vallance J, Febvey-Combes O, Perol D, Canada B, Roitmann E, Dufresne A, Bachelot T, Heudel PE, Tredan O, Touillaud M, Pialoux V. A Personalized Physical Activity Program With Activity Trackers and a Mobile Phone App for Patients With Metastatic Breast Cancer: Protocol for a Single-Arm Feasibility Trial. JMIR Res Protoc. 7(8): p. e10487, 2018.
  7. Garnier Y, Ferdinand S, Connes P, Garnier M, Etienne-Julan M, Lemonne N, Romana M. Decrease of externalized phosphatidylserine density on red blood cell-derived microparticles in SCA patients treated with hydroxycarbamide. Br J Haematol. 182(3): p. 448-451, 2018.
  8. Jung F, Connes P, Lehmann C. A.L. Copley Best Paper Prize 2017. Clin Hemorheol Microcirc. 68(4): p. 333-334, 2018.
  9. Lalanne-Mistrih ML, Connes P, Lamarre Y, Lemonne N, Hardy-Dessources MD, Tarer V, Etienne-Julan M, Mougenel D, Tressieres B, Romana M. Lipid profiles in French West Indies sickle cell disease cohorts, and their general population. Lipids Health Dis. 17(1): p. 38, 2018.
  10. Lapoumeroulie C, Connes P, El Hoss S, Hierso R, Charlot K, Lemonne N, Elion J, Le Van Kim C, Romana M, Hardy-Dessources MD. New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises. Br J Haematol. 10.1111/bjh.15686, 2018.
  11. Martin C, Pialoux V, Faes C, Charrin E, Skinner S, Connes P. Does physical activity increase or decrease the risk of sickle cell disease complications? Br J Sports Med. 52(4): p. 214-218, 2018.
  12. Mury P, Chirico EN, Mura M, Millon A, Canet-Soulas E, Pialoux V. Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity. Sports Med. 48(12): p. 2725-2741, 2018.
  13. Nader E, Grau M, Fort R, Collins B, Cannas G, Gauthier A, Walpurgis K, Martin C, Bloch W, Poutrel S, Hot A, Renoux C, Thevis M, Joly P, Romana M, Guillot N, Connes P. Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway. Nitric Oxide. 81: p. 28-35, 2018.
  14. Nader E, Guillot N, Lavorel L, Hancco I, Fort R, Stauffer E, Renoux C, Joly P, Germain M, Connes P. Eryptosis and hemorheological responses to maximal exercise in athletes: Comparison between running and cycling. Scand J Med Sci Sports. 28(5): p. 1532-1540, 2018.
  15. Ouedraogo V, Connes P, Tripette J, Tiendrebeogo AJF, Sow AK, Diaw M, Seck M, Diop M, Hallab M, Belue R, Samb A, Ba A, Leftheriotis G. Pulse wave velocity is lower in trained than in untrained sickle cell trait carriers. Clin Hemorheol Microcirc. 69(3): p. 417-424, 2018.
  16. Renoux C, Joly P, Faes C, Mury P, Eglenen B, Turkay M, Yavas G, Yalcin O, Bertrand Y, Garnier N, Cuzzubbo D, Gauthier A, Romana M, Mockesch B, Cannas G, Antoine-Jonville S, Pialoux V, Connes P. Association between Oxidative Stress, Genetic Factors, and Clinical Severity in Children with Sickle Cell Anemia. J Pediatr. 195: p. 228-235, 2018.
  17. Renoux C, Joly P, Gauthier A, Pialoux V, Romanet-Faes C, Bertrand Y, Garnier N, Cuzzubbo D, Cannas G, Connes P. Blood rheology in children with the S/beta+-thalassemia syndrome. Clin Hemorheol Microcirc. 69(1-2): p. 207-214, 2018.
  18. Romana M, Connes P, Key NS. Microparticles in sickle cell disease. Clin Hemorheol Microcirc. 68(2-3): p. 319-329, 2018.
  19. Sabrie M, Cannas G, Tazarourte K, Poutrel S, Connes P, Hot A, Renoux C, Fattoum J, Joly P. Drepa-Opia: A Pilot Study to Determine the Predictive Factors of Morphine Use and Consumption in Hospitalized Adult Patients with Sickle Cell Disease. Hemoglobin. 42(4): p. 217-224, 2018.
  20. Skinner S, Pialoux V, Fromy B, Sigaudo-Roussel D, Connes P. Sickle-cell trait and diagnosis of type 2 diabetes. Lancet Diabetes Endocrinol. 6(11): p. 840-843, 2018.
  21. Skinner SC, Diaw M, Pialoux V, Mbaye MN, Mury P, Lopez P, Bousquet D, Gueye F, Diedhiou D, Joly P, Renoux C, Sow D, Diop S, Ranque B, Vinet A, Samb A, Guillot N, Connes P. Increased Prevalence of Type 2 Diabetes-Related Complications in Combined Type 2 Diabetes and Sickle Cell Trait. Diabetes Care. 41(12): p. 2595-2602, 2018.
  22. Tossea SK, Adji EG, Coulibaly B, Ako BA, Coulibaly DN, Joly P, Assi SB, Toure A, Jambou R. Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast. BMC Res Notes. 11(1): p. 215, 2018.




  1. Cannas G, Poutrel S, Thomas X. Hydroxycarbamine: from an Old Drug Used in Malignant Hemopathies to a Current Standard in Sickle Cell Disease. Mediterr J Hematol Infect Dis. 9(1): p. e2017015, 2017.
  2. Charlot K, Antoine-Jonville S, Moeckesch B, Jumet S, Romana M, Waltz X, Divialle-Doumdo L, Hardy-Dessources MD, Petras M, Tressieres B, Tarer V, Hue O, Etienne-Julan M, Connes P. Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion. Blood Cells Mol Dis. 65: p. 23-28, 2017.
  3. Charlot K, Hierso R, Lemonne N, Romana M, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M, Tarer V, Ferracci S, Hardy-Dessources MD, Connes P. Changes in autonomic nervous activity during vaso-occlusive crisis in patients with sickle cell anaemia. Br J Haematol. 177(3): p. 484-486, 2017.
  4. Debevec T, Millet GP, Pialoux V. Hypoxia-Induced Oxidative Stress Modulation with Physical Activity. Front Physiol. 8: p. 84, 2017.
  5. Garnier Y, Ferdinand S, Etienne-Julan M, Elana G, Petras M, Doumdo L, Tressieres B, Lalanne-Mistrih ML, Hardy-Dessources MD, Connes P, Romana M. Differences of microparticle patterns between sickle cell anemia and hemoglobin SC patients. PLoS One. 12(5): p. e0177397, 2017.
  6. Gueye Tall F, Martin C, Malick Ndour EH, Deme Ly I, Renoux C, Chillotti L, Veyrenche N, Connes P, Madieye Gueye P, Ndiaye Diallo R, Lacan P, Diagne I, Amadou Diop P, Cisse A, Lopez Sall P, Joly P. Genetic Background of the Sickle Cell Disease Pediatric Population of Dakar, Senegal, and Characterization of a Novel Frameshift beta-Thalassemia Mutation [HBB: c.265_266del; p.Leu89Glufs*2]. Hemoglobin. 41(2): p. 89-95, 2017.
  7. Hierso R, Lemonne N, Villaescusa R, Lalanne-Mistrih ML, Charlot K, Etienne-Julan M, Tressieres B, Lamarre Y, Tarer V, Garnier Y, Hernandez AA, Ferracci S, Connes P, Romana M, Hardy-Dessources MD. Exacerbation of oxidative stress during sickle vaso-occlusive crisis is associated with decreased anti-band 3 autoantibodies rate and increased red blood cell-derived microparticle level: a prospective study. Br J Haematol. 176(5): p. 805-813, 2017.
  8. Joly P, Renoux C, Lacan P, Bertrand Y, Cannas G, Garnier N, Cuzzubbo D, Kebaili K, Renard C, Gauthier A, Pialoux V, Martin C, Romana M, Connes P. UGT1A1 (TA)n genotype is not the major risk factor of cholelithiasis in sickle cell disease children. Eur J Haematol. 98(3): p. 296-301, 2017.
  9. Joly P, Vignaud H, Di Martino J, Ruiz M, Garin R, Restier L, Belmalih A, Marchal C, Cullin C, Arveiler B, Fergelot P, Gitler AD, Lachaux A, Couthouis J, Bouchecareilh M. ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency. PLoS One. 12(6): p. e0179369, 2017.
  10. Jung F, Connes P, Lehmann C. A.L. Copley Best Paper Prize 2016. Clin Hemorheol Microcirc. 66(3): p. 185-186, 2017.
  11. Khalyfa A, Youssefnia N, Foster GE, Beaudin AE, Qiao Z, Pialoux V, Pun M, Hanly PJ, Kheirandish-Gozal L, Poulin MJ, Gozal D. Plasma Exosomes and Improvements in Endothelial Function by Angiotensin 2 Type 1 Receptor or Cyclooxygenase 2 Blockade following Intermittent Hypoxia. Front Neurol. 8: p. 709, 2017.
  12. Laouafa S, Ribon-Demars A, Marcouiller F, Roussel D, Bairam A, Pialoux V, Joseph V. Estradiol Protects Against Cardiorespiratory Dysfunctions and Oxidative Stress in Intermittent Hypoxia. Sleep. 40(8), 2017.
  13. Le Moal E, Pialoux V, Juban G, Groussard C, Zouhal H, Chazaud B, Mounier R. Redox Control of Skeletal Muscle Regeneration. Antioxid Redox Signal. 27(5): p. 276-310, 2017.
  14. Lemonne N, Mockesch B, Charlot K, Garnier Y, Waltz X, Lamarre Y, Antoine-Jonville S, Etienne-Julan M, Hardy-Dessources MD, Romana M, Connes P. Effects of hydroxyurea on blood rheology in sickle cell anemia: A two-years follow-up study. Clin Hemorheol Microcirc. 67(2): p. 141-148, 2017.
  15. Millet GP, Debevec T, Brocherie F, Girard O, Pialoux V, Wust RC, Degens H, Zuo L, He F, Chaillou T, Cheng A, Kayser B, Favier FB, Begue G, Murray AJ, Horscroft JA. Commentaries on Viewpoint: Human skeletal muscle wasting in hypoxia: a matter of hypoxic dose? J Appl Physiol (1985). 122(2): p. 409-411, 2017.
  16. Mockesch B, Charlot K, Jumet S, Romana M, Divialle-Doumdo L, Hardy-Dessources MD, Petras M, Tressieres B, Tarer V, Hue O, Etienne-Julan M, Connes P, Antoine-Jonville S. Micro- and macrovascular function in children with sickle cell anaemia and sickle cell haemoglobin C disease. Blood Cells Mol Dis. 64: p. 23-29, 2017.
  17. Mockesch B, Connes P, Charlot K, Skinner S, Hardy-Dessources MD, Romana M, Jumet S, Petras M, Divialle-Doumdo L, Martin C, Tressieres B, Tarer V, Hue O, Etienne-Julan M, Antoine S, Pialoux V. Association between oxidative stress and vascular reactivity in children with sickle cell anaemia and sickle haemoglobin C disease. Br J Haematol. 178(3): p. 468-475, 2017.
  18. Mury P, Faes C, Millon A, Mura M, Renoux C, Skinner S, Nicaise V, Joly P, Della Schiava N, Lermusiaux P, Connes P, Pialoux V. Higher Daily Physical Activity Level Is Associated with Lower RBC Aggregation in Carotid Artery Disease Patients at High Risk of Stroke. Front Physiol. 8: p. 1043, 2017.
  19. Nader E, Connes P, Lamarre Y, Renoux C, Joly P, Hardy-Dessources MD, Cannas G, Lemonne N, Ballas SK. Plasmapheresis may improve clinical condition in sickle cell disease through its effects on red blood cell rheology. Am J Hematol. 92(11): p. E629-E630, 2017.
  20. Orvain C, Joly P, Pissard S, Badiou S, Badens C, Bonello-Palot N, Couque N, Gulbis B, Aguilar-Martinez P. Diagnostic approach to hemoglobins with high oxygen affinity: experience from France and Belgium and review of the literature. Ann Biol Clin (Paris). 75(1): p. 39-51, 2017.
  21. Pialoux V, Poulin MJ, Hemmelgarn BR, Muruve DA, Chirico EN, Faes C, Sola DY, Ahmed SB. Cyclooxygenase-2 Inhibition Limits Angiotensin II-Induced DNA Oxidation and Protein Nitration in Humans. Front Physiol. 8: p. 138, 2017.
  22. Renoux C, Connes P, Nader E, Skinner S, Faes C, Petras M, Bertrand Y, Garnier N, Cuzzubbo D, Divialle-Doumdo L, Kebaili K, Renard C, Gauthier A, Etienne-Julan M, Cannas G, Martin C, Hardy-Dessources MD, Pialoux V, Romana M, Joly P. Alpha-thalassaemia promotes frequent vaso-occlusive crises in children with sickle cell anaemia through haemorheological changes. Pediatr Blood Cancer. 64(8), 2017.
  23. Sornjai W, Lithanatudom P, Erales J, Joly P, Francina A, Hacot S, Fucharoen S, Svasti S, Diaz JJ, Mertani HC, Smith DR. Hypermethylation of 28S ribosomal RNA in beta-thalassemia trait carriers. Int J Biol Macromol. 94(Pt A): p. 728-734, 2017.




  1. Charlot K, Romana M, Moeckesch B, Jumet S, Waltz X, Divialle-Doumdo L, Hardy-Dessources MD, Petras M, Tressieres B, Tarer V, Hue O, Etienne-Julan M, Antoine-Jonville S, Connes P. Which side of the balance determines the frequency of vaso-occlusive crises in children with sickle cell anemia: Blood viscosity or microvascular dysfunction? Blood Cells Mol Dis. 56(1): p. 41-5, 2016.
  2. Charrin E, Ofori-Acquah SF, Nader E, Skinner S, Connes P, Pialoux V, Joly P, Martin C. Inflammatory and oxidative stress phenotypes in transgenic sickle cell mice. Blood Cells Mol Dis. 62: p. 13-21, 2016.
  3. Chirico EN, Di Cataldo V, Chauveau F, Geloen A, Patsouris D, Theze B, Martin C, Vidal H, Rieusset J, Pialoux V, Canet-Soulas E. Magnetic resonance imaging biomarkers of exercise-induced improvement of oxidative stress and inflammation in the brain of old high-fat-fed ApoE(-/-) mice. J Physiol. 594(23): p. 6969-6985, 2016.
  4. Chirico EN, Faes C, Connes P, Canet-Soulas E, Martin C, Pialoux V. Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease. Sports Med. 46(5): p. 629-39, 2016.
  5. Cita KC, Brureau L, Lemonne N, Billaud M, Connes P, Ferdinand S, Tressieres B, Tarer V, Etienne-Julan M, Blanchet P, Elion J, Romana M. Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength. PLoS One. 11(5): p. e0154866, 2016.
  6. Cita KC, Ferdinand S, Connes P, Brudey L, Tressieres B, Etienne-Julan M, Lemonne N, Tarer V, Elion J, Romana M. Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia. Blood Cells Mol Dis. 58: p. 21-5, 2016.
  7. Connes P, Alexy T, Detterich J, Romana M, Hardy-Dessources MD, Ballas SK. The role of blood rheology in sickle cell disease. Blood Rev. 30(2): p. 111-8, 2016.
  8. Debevec T, Pialoux V, Ehrstrom S, Ribon A, Eiken O, Mekjavic IB, Millet GP. FemHab: The effects of bed rest and hypoxia on oxidative stress in healthy women. J Appl Physiol (1985). 120(8): p. 930-8, 2016.
  9. Delacour H, Konopacki J, Plantamura J, Lacan P, Joly P. Hb Hope [beta136Gly-->Asp] and Hb Grady [alpha119_120insGluPheThr] compound heterozygosity in a Mauritanian patient. Clin Chem Lab Med. 54(2): p. e35-6, 2016.
  10. Di Cataldo V, Geloen A, Langlois JB, Chauveau F, Theze B, Hubert V, Wiart M, Chirico EN, Rieusset J, Vidal H, Pialoux V, Canet-Soulas E. Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE(-/-) Mice. Front Physiol. 7: p. 453, 2016.
  11. Friedenreich CM, Pialoux V, Wang Q, Shaw E, Brenner DR, Waltz X, Conroy SM, Johnson R, Woolcott CG, Poulin MJ, Courneya KS. Effects of exercise on markers of oxidative stress: an Ancillary analysis of the Alberta Physical Activity and Breast Cancer Prevention Trial. BMJ Open Sport Exerc Med. 2(1): p. e000171, 2016.
  12. Gastebois C, Chanon S, Rome S, Durand C, Pelascini E, Jalabert A, Euthine V, Pialoux V, Blanc S, Simon C, Lefai E. Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance. Physiol Rep. 4(17), 2016.
  13. Jiang Z, Luo HY, Huang S, Farrell JJ, Davis L, Theberge R, Benson KA, Riolueang S, Viprakasit V, Al-Allawi NA, Unal S, Gumruk F, Akar N, Basak AN, Osorio L, Badens C, Pissard S, Joly P, Campbell AD, Gallagher PG, Steinberg MH, Forget BG, Chui DH. The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) beta(0) -thalassaemia homozygotes. Br J Haematol. 172(6): p. 958-65, 2016.
  14. Joly P, Garnier N, Kebaili K, Renoux C, Dony A, Cheikh N, Renard C, Ceraulo A, Cuzzubbo D, Pondarre C, Martin C, Pialoux V, Francina A, Bertrand Y, Connes P. G6PD deficiency and absence of alpha-thalassemia increase the risk for cerebral vasculopathy in children with sickle cell anemia. Eur J Haematol. 96(4): p. 404-8, 2016.
  15. Khalyfa A, Khalyfa AA, Akbarpour M, Connes P, Romana M, Lapping-Carr G, Zhang C, Andrade J, Gozal D. Extracellular microvesicle microRNAs in children with sickle cell anaemia with divergent clinical phenotypes. Br J Haematol. 174(5): p. 786-98, 2016.
  16. Lemonne N, Billaud M, Waltz X, Romana M, Hierso R, Etienne-Julan M, Connes P. Rheology of red blood cells in patients with HbC disease. Clin Hemorheol Microcirc. 61(4): p. 571-7, 2016.
  17. Mozar A, Connes P, Collins B, Hardy-Dessources MD, Romana M, Lemonne N, Bloch W, Grau M. Red blood cell nitric oxide synthase modulates red blood cell deformability in sickle cell anemia. Clin Hemorheol Microcirc. 64(1): p. 47-53, 2016.
  18. Pichon AP, Connes P, Robach P. Effects of acute and chronic hematocrit modulations on blood viscosity in endurance athletes. Clin Hemorheol Microcirc. 64(2): p. 115-123, 2016.
  19. Renoux C, Parrow N, Faes C, Joly P, Hardeman M, Tisdale J, Levine M, Garnier N, Bertrand Y, Kebaili K, Cuzzubbo D, Cannas G, Martin C, Connes P. Importance of methodological standardization for the ektacytometric measures of red blood cell deformability in sickle cell anemia. Clin Hemorheol Microcirc. 62(2): p. 173-9, 2016.
  20. Renoux C, Romana M, Joly P, Ferdinand S, Faes C, Lemonne N, Skinner S, Garnier N, Etienne-Julan M, Bertrand Y, Petras M, Cannas G, Divialle-Doumdo L, Nader E, Cuzzubbo D, Lamarre Y, Gauthier A, Waltz X, Kebaili K, Martin C, Hot A, Hardy-Dessources MD, Pialoux V, Connes P. Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study. PLoS One. 11(6): p. e0158182, 2016.
  21. Sandor B, Marin M, Lapoumeroulie C, Rabai M, Lefevre SD, Lemonne N, El Nemer W, Mozar A, Francais O, Le Pioufle B, Connes P, Le Van Kim C. Effects of Poloxamer 188 on red blood cell membrane properties in sickle cell anaemia. Br J Haematol. 173(1): p. 145-9, 2016.
  22. Simonnet C, Elanga N, Joly P, Vaz T, Nacher M. Genetic modulators of sickle cell disease in French Guiana: Markers of the slave trade. Am J Hum Biol. 28(6): p. 811-816, 2016.




  1. Ballas SK, Connes P. The paradox of the serrated sickle erythrocyte: The importance of the red blood cell membrane topography. Clin Hemorheol Microcirc. 63(2): p. 149-52, 2015.
  2. Caillaud C, Connes P, Ben Saad H, Mercier J. Erythropoietin enhances whole body lipid oxidation during prolonged exercise in humans. J Physiol Biochem. 71(1): p. 9-16, 2015.
  3. Charlot K, Moeckesch B, Jumet S, Romana M, Waltz X, Divialle-Doumdo L, Hardy-Dessources MD, Petras M, Tressieres B, Pichon A, Tarer V, Hue O, Etienne-Julan M, Antoine-Jonville S, Connes P. Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study. Pediatr Blood Cancer. 62(11): p. 1962-7, 2015.
  4. Charlot K, Waltz X, Hedreville M, Sinnapah S, Lemonne N, Etienne-Julan M, Soter V, Hue O, Hardy-Dessources MD, Connes P. Impaired oxygen uptake efficiency slope and off-transient kinetics of pulmonary oxygen uptake in sickle cell anemia are associated with hemorheological abnormalities. Clin Hemorheol Microcirc. 60(4): p. 413-21, 2015.
  5. Charrin E, Aufradet E, Douillard A, Romdhani A, Souza GD, Bessaad A, Faes C, Chirico EN, Pialoux V, Martin C. Oxidative stress is decreased in physically active sickle cell SAD mice. Br J Haematol. 168(5): p. 747-56, 2015.
  6. Connes P. Obstructive sleep apnea and sickle cell disease: Towards hemorheological abnormalities and vascular dysfunction worsening. Sleep Med Rev. 24: p. 101-2, 2015.
  7. Connes P. Sickle cell trait, exertional rhabdomyolysis, and compartment syndrome. Lancet. 385(9981): p. 1948, 2015.
  8. Danjou F, Francavilla M, Anni F, Satta S, Demartis FR, Perseu L, Manca M, Sollaino MC, Manunza L, Mereu E, Marceddu G, Pissard S, Joly P, Thuret I, Origa R, Borg J, Forni GL, Piga A, Lai ME, Badens C, Moi P, Galanello R. A genetic score for the prediction of beta-thalassemia severity. Haematologica. 100(4): p. 452-7, 2015.
  9. Debevec T, Pialoux V, Saugy J, Schmitt L, Cejuela R, Mury P, Ehrstrom S, Faiss R, Millet GP. Prooxidant/Antioxidant Balance in Hypoxia: A Cross-Over Study on Normobaric vs. Hypobaric "Live High-Train Low". PLoS One. 10(9): p. e0137957, 2015.
  10. Diaw M, Diop S, Soubaiga FY, Seck M, Faye BF, Niang MN, Samb A, Connes P. Blood viscosity is lower in trained than in sedentary sickle cell trait carriers. Clin Hemorheol Microcirc. 61(1): p. 23-9, 2015.
  11. Diaw M, Pialoux V, Martin C, Samb A, Diop S, Faes C, Mury P, Sall Diop N, Diop SN, Ranque B, Mbaye MN, Key NS, Connes P. Sickle Cell Trait Worsens Oxidative Stress, Abnormal Blood Rheology, and Vascular Dysfunction in Type 2 Diabetes. Diabetes Care. 38(11): p. 2120-7, 2015.
  12. Faes C, Charrin E, Connes P, Pialoux V, Martin C. Chronic physical activity limits blood rheology alterations in transgenic SAD mice. Am J Hematol. 90(2): p. E32-3, 2015.
  13. Ferdinand S, Connes P, Brudey L, Cita KC, Tressieres B, Lemonne N, Hardy-Dessources MD, Lamarre Y, Waltz X, Etienne-Julan M, Romana M. Impact of eNOS polymorphisms on red blood cell aggregation in sickle cell disease. Blood Cells Mol Dis. 55(2): p. 151-3, 2015.
  14. Grau M, Mozar A, Charlot K, Lamarre Y, Weyel L, Suhr F, Collins B, Jumet S, Hardy-Dessources MD, Romana M, Lemonne N, Etienne-Julan M, Antoine-Jonville S, Bloch W, Connes P. High red blood cell nitric oxide synthase activation is not associated with improved vascular function and red blood cell deformability in sickle cell anaemia. Br J Haematol. 168(5): p. 728-36, 2015.
  15. Joly P, Guillaud O, Hervieu V, Francina A, Mornex JF, Chapuis-Cellier C. Clinical heterogeneity and potential high pathogenicity of the Mmalton Alpha 1 antitrypsin allele at the homozygous, compound heterozygous and heterozygous states. Orphanet J Rare Dis. 10: p. 130, 2015.
  16. Joly P, Restier L, Bouchecareilh M, Lacan P, Cabet F, Chapuis-Cellier C, Francina A, Lachaux A. [DEFI-ALPHA cohort and POLYGEN DEFI-ALPHA clinical research hospital programme. A study about clinical, biological and genetics factors associated with the occurrence and the evolution of hepatic complications in children with alpha-1 antitrypsin deficiency]. Rev Mal Respir. 32(7): p. 759-67, 2015.
  17. Key NS, Connes P, Derebail VK. Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory. Br J Haematol. 170(1): p. 5-14, 2015.
  18. Lemonne N, Charlot K, Waltz X, Ballas SK, Lamarre Y, Lee K, Hierso R, Connes C, Etienne-Julan M, Romana M, Connes P. Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia. Haematologica. 100(10): p. e383-6, 2015.
  19. Lobo CL, do Nascimento EM, Abelha R, Queiroz AM, Connes P, Cardoso GP, Ballas SK. Risk Factors of Pulmonary Hypertension in Brazilian Patients with Sickle Cell Anemia. PLoS One. 10(9): p. e0137539, 2015.
  20. Mozar A, Charlot K, Sandor B, Rabai M, Lemonne N, Billaud M, Hardy-Dessources MD, Beltan E, Pandey RC, Connes P, Ballas SK. Pfaffia paniculata extract improves red blood cell deformability in sickle cell patients. Clin Hemorheol Microcirc. 62(4): p. 327-33, 2015.
  21. Prieur F, Pialoux V, Mestas JL, Mury P, Skinner S, Lafon C. Evaluation of inertial cavitation activity in tissue through measurement of oxidative stress. Ultrason Sonochem. 26: p. 193-199, 2015.
  22. Renoux C, Feray C, Joly P, Lacan P, Francina A. Description of Three New alpha Variants and Four New beta Variants: Hb Montluel [alpha110(G17)Ala --> Val; HBA1: c.332C > T], Hb Cap d'Agde [alpha131(H14)Ser --> Cys; HBA2: c.395C > G] and Hb Corsica [alpha100(G7)Leu --> Pro; HBA1: 302T > C]; Hb Nimes [beta104(G6)Arg --> Gly; HBB: c.313A > G], Hb Saint Marcellin [beta112(G14)Cys --> Gly; HBB: c.337T > G], Hb Saint Chamond [beta80(EF4)Asn --> 0; HBB: c.241_243delAAC] and Hb Dompierre [beta29(B11)Gly --> Arg; HBB: c.88G > C]. Hemoglobin. 39(3): p. 147-51, 2015.
  23. Renoux C, Feray C, Joly P, Zanella-Cleon I, Garcia C, Lacan P, Couprie N, Francina A. A new hemoglobin variant: Hb Meylan [beta73(E17)Asp --> Phe; HBB: c.220G>T; c.221A>T] with a double base mutation at the same codon. Hemoglobin. 39(1): p. 46-8, 2015.
  24. Ruiz M, Joly P, Lachaux A. Severe Liver Disease in Children With alpha-1 Antitrypsin Deficiency in France (DEFI-ALPHA Cohort). J Pediatr Gastroenterol Nutr. 61(5): p. e25, 2015.
  25. Sinnapah S, Cadelis G, Waltz X, Lamarre Y, Connes P. Overweight explains the increased red blood cell aggregation in patients with obstructive sleep apnea. Clin Hemorheol Microcirc. 59(1): p. 17-26, 2015.
  26. Vent-Schmidt J, Waltz X, Pichon A, Hardy-Dessources MD, Romana M, Connes P. Indirect viscosimetric method is less accurate than ektacytometry for the measurement of red blood cell deformability. Clin Hemorheol Microcirc. 59(2): p. 115-21, 2015.
  27. Vinatier I, Martin X, Costa JM, Bazin A, Giraudier S, Joly P. A late onset sickle cell disease reveals a mosaic segmental uniparental isodisomy of chromosome 11p15. Blood Cells Mol Dis. 54(1): p. 53-5, 2015.
  28. Waltz X, Hardy-Dessources MD, Lemonne N, Mougenel D, Lalanne-Mistrih ML, Lamarre Y, Tarer V, Tressieres B, Etienne-Julan M, Hue O, Connes P. Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle? Clin Hemorheol Microcirc. 59(1): p. 37-43, 2015.




  1. Aufradet E, Douillard A, Charrin E, Romdhani A, De Souza G, Bessaad A, Faes C, Bourgeaux V, Chirico EN, Canet-Soulas E, Pialoux V, Martin C. Physical activity limits pulmonary endothelial activation in sickle cell SAD mice. Blood. 123(17): p. 2745-7, 2014.
  2. Balduyck M, Chapuis Cellier C, Roche D, Odou MF, Joly P, Madelain V, Vergne A, Nouadje G, Lafitte JJ, Porchet N, Beaune P, Zerimech F. [Development of a laboratory test on dried blood spots for facilitating early diagnosis of alpha-1-antitrypsin deficiency]. Ann Biol Clin (Paris). 72(6): p. 689-704, 2014.
  3. Debevec T, Pialoux V, Mekjavic IB, Eiken O, Mury P, Millet GP. Moderate exercise blunts oxidative stress induced by normobaric hypoxic confinement. Med Sci Sports Exerc. 46(1): p. 33-41, 2014.
  4. Diaw M, samb A, Diop S, Sall ND, Ba A, Cisse F, Connes P. Effects of hydration and water deprivation on blood viscosity during a soccer game in sickle cell trait carriers. Br J Sports Med. 48(4): p. 326-31, 2014.
  5. Faes C, Balayssac-Siransy E, Connes P, Hivert L, Danho C, Bogui P, Martin C, Pialoux V. Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation. Br J Haematol. 164(1): p. 124-30, 2014.
  6. Giardine B, Borg J, Viennas E, Pavlidis C, Moradkhani K, Joly P, Bartsakoulia M, Riemer C, Miller W, Tzimas G, Wajcman H, Hardison RC, Patrinos GP. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res. 42(Database issue): p. D1063-9, 2014.
  7. Hedreville M, Charlot K, Waltz X, Sinnapah S, Lemonne N, Etienne-Julan M, Soter V, Hue O, Hardy-Dessources MD, Barthelemy JC, Connes P. Acute moderate exercise does not further alter the autonomic nervous system activity in patients with sickle cell anemia. PLoS One. 9(4): p. e95563, 2014.
  8. Hierso R, Waltz X, Mora P, Romana M, Lemonne N, Connes P, Hardy-Dessources MD. Effects of oxidative stress on red blood cell rheology in sickle cell patients. Br J Haematol. 166(4): p. 601-6, 2014.
  9. Joly P, Pondarre C, Badens C. [Beta-thalassemias: molecular, epidemiological, diagnostical and clinical aspects]. Ann Biol Clin (Paris). 72(6): p. 639-68, 2014.
  10. Lamarre Y, Hardy-Dessources MD, Romana M, Lalanne-Mistrih ML, Waltz X, Petras M, Doumdo L, Blanchet-Deverly A, Martino J, Tressieres B, Maillard F, Tarer V, Etienne-Julan M, Connes P. Relationships between systemic vascular resistance, blood rheology and nitric oxide in children with sickle cell anemia or sickle cell-hemoglobin C disease. Clin Hemorheol Microcirc. 58(2): p. 307-16, 2014.
  11. Lamarre Y, Romana M, Lemonne N, Hardy-Dessources MD, Tarer V, Mougenel D, Waltz X, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M, Connes P. Alpha thalassemia protects sickle cell anemia patients from macro-albuminuria through its effects on red blood cell rheological properties. Clin Hemorheol Microcirc. 57(1): p. 63-72, 2014.
  12. Lemonne N, Lamarre Y, Romana M, Hardy-Dessources MD, Lionnet F, Waltz X, Tarer V, Mougenel D, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M, Connes P. Impaired blood rheology plays a role in the chronic disorders associated with sickle cell-hemoglobin C disease. Haematologica. 99(5): p. 74-5, 2014.
  13. Lemonne N, Romana M, Lamarre Y, Hardy-Dessources MD, Lionnet F, Waltz X, Tarer V, Mougenel D, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M, Connes P. Association between relative systemic hypertension and otologic disorders in patients with sickle cell-hemoglobin C disorder. Am J Hematol. 89(6): p. 667, 2014.
  14. Nebor D, Bowers A, Connes P, Hardy-Dessources MD, Knight-Madden J, Cumming V, Reid M, Romana M. Plasma concentration of platelet-derived microparticles is related to painful vaso-occlusive phenotype severity in sickle cell anemia. PLoS One. 9(1): p. e87243, 2014.
  15. Pichon A, Lamarre Y, Voituron N, Marchant D, Vilar J, Richalet JP, Connes P. Red blood cell deformability is very slightly decreased in erythropoietin deficient mice. Clin Hemorheol Microcirc. 56(1): p. 41-6, 2014.
  16. Qadah T, Finlayson J, Joly P, Ghassemifar R. Molecular and cellular analysis of a novel HBA2 mutation (HBA2: c.94A > G) shows activation of a cryptic splice site and generation of a premature termination codon. Hemoglobin. 38(1): p. 13-8, 2014.
  17. Simmonds MJ, Detterich JA, Connes P. Nitric oxide, vasodilation and the red blood cell. Biorheology. 51(2-3): p. 121-34, 2014.
  18. Vent-Schmidt J, Waltz X, Romana M, Hardy-Dessources MD, Lemonne N, Billaud M, Etienne-Julan M, Connes P. Blood thixotropy in patients with sickle cell anaemia: role of haematocrit and red blood cell rheological properties. PLoS One. 9(12): p. e114412, 2014.
  19. Waltz X, Baillot M, Connes P, Bocage B, Renaudeau D. Effects of hydration level and heat stress on thermoregulatory responses, hematological and blood rheological properties in growing pigs. PLoS One. 9(7): p. e102537, 2014.
  20. Waltz X, Baillot M, Connes P, Gourdine JL, Philibert L, Beltan E, Chalabi T, Renaudeau D. Effect of heat stress on blood rheology in different pigs breeds. Clin Hemorheol Microcirc. 58(3): p. 395-402, 2014.