Les publications

Les publicationsThématique 2

Déconditionnement et reconditionnement musculaire



  1. Chatel B, Messonnier LA, Vilmen C, Bernard M, Pialoux V, Bendahan D. Ischaemia-induced muscle metabolic abnormalities are poorly alleviated by endurance training in a mouse model of sickle cell disease. Exp Physiol. 104(3): p. 398-406, 2019.
  2. Merlet AN, Chatel B, Hourde C, Ravelojaona M, Bendahan D, Feasson L, Messonnier LA. How Sickle Cell Disease Impairs Skeletal Muscle Function: Implications in Daily Life. Med Sci Sports Exerc. 51(1): p. 4-11, 2019.




  1. Balog J, Goossens R, Lemmers R, Straasheijm KR, van der Vliet PJ, Heuvel AVD, Cambieri C, Capet N, Feasson L, Manel V, Contet J, Kriek M, Donlin-Smith CM, Ruivenkamp CAL, Heard P, Tapscott SJ, Cody JD, Tawil R, Sacconi S, van der Maarel SM. Monosomy 18p is a risk factor for facioscapulohumeral dystrophy. J Med Genet. 55(7): p. 469-478, 2018.
  2. Britto FA, Cortade F, Belloum Y, Blaquiere M, Gallot YS, Docquier A, Pagano AF, Jublanc E, Bendridi N, Koechlin-Ramonatxo C, Chabi B, Francaux M, Casas F, Freyssenet D, Rieusset J, Giorgetti-Peraldi S, Carnac G, Ollendorff V, Favier FB. Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress. BMC Biol. 16(1): p. 65, 2018.
  3. Chatel B, Messonnier LA, Barge Q, Vilmen C, Noirez P, Bernard M, Pialoux V, Bendahan D. Endurance training reduces exercise-induced acidosis and improves muscle function in a mouse model of sickle cell disease. Mol Genet Metab. 123(3): p. 400-410, 2018.
  4. Chatel B, Messonnier LA, Bendahan D. Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease? Exp Physiol. 103(9): p. 1213-1220, 2018.
  5. Chatel B, Messonnier LA, Vilmen C, Bernard M, Pialoux V, Bendahan D. Exacerbated metabolic changes in skeletal muscle of sickle cell mice submitted to an acute ischemia-reperfusion paradigm. Clin Sci (Lond). 132(19): p. 2103-2115, 2018.
  6. Dalle C, Ostermann AI, Konrad T, Coudy-Gandilhon C, Decourt A, Barthelemy JC, Roche F, Feasson L, Mazur A, Bechet D, Schebb NH, Gladine C. Muscle loss associated changes of oxylipin signatures during biological aging: an exploratory study from the PROOF cohort. J Gerontol A Biol Sci Med Sci. 10.1093/gerona/gly187, 2018.
  7. Eyenga P, Roussel D, Morel J, Rey B, Romestaing C, Gueguen-Chaignon V, Sheu SS, Viale JP. Time course of liver mitochondrial function and intrinsic changes in oxidative phosphorylation in a rat model of sepsis. Intensive Care Med Exp. 6(1): p. 31, 2018.
  8. Galusca B, Verney J, Meugnier E, Ling Y, Edouard P, Feasson L, Ravelojaona M, Vidal H, Estour B, Germain N. Reduced fibre size, capillary supply and mitochondrial activity in constitutional thinness' skeletal muscle. Acta Physiol (Oxf). 224(3): p. e13097, 2018.
  9. Gellen B, Messonnier LA, Galacteros F, Audureau E, Merlet AN, Rupp T, Peyrot S, Martin C, Feasson L, Bartolucci P. Moderate-intensity endurance-exercise training in patients with sickle-cell disease without severe chronic complications (EXDRE): an open-label randomised controlled trial. Lancet Haematol. 5(11): p. e554-e562, 2018.
  10. Grand N, Bouchet JB, Zufferey P, Beraud AM, Awad S, Sandri F, Campisi S, Fuzellier JF, Molliex S, Vola M, Morel J. Quality of Life After Cardiac Operations Based on the Minimal Clinically Important Difference Concept. Ann Thorac Surg. 106(2): p. 548-554, 2018.
  11. Gris JC, Cochery-Nouvellon E, Bouvier S, Jaber S, Albanese J, Constantin JM, Orban JC, Morel J, Leone M, Deras P, Elotmani L, Lavigne-Lissalde G, Lefrant JY. Clinical value of automated fibrin generation markers in patients with septic shock: a SepsiCoag ancillary study. Br J Haematol. 183(4): p. 636-647, 2018.
  12. Morgan JE, Prola A, Mariot V, Pini V, Meng J, Hourde C, Dumonceaux J, Conti F, Relaix F, Authier FJ, Tiret L, Muntoni F, Bencze M. Necroptosis mediates myofibre death in dystrophin-deficient mice. Nat Commun. 9(1): p. 3655, 2018.
  13. Rochette E, Merlin E, Hourde C, Evrard B, Peraira B, Echaubard S, Duche P. Inflammatory Response 24 h Post-Exercise in Youth with Juvenile Idiopathic Arthritis. Int J Sports Med. 39(11): p. 867-874, 2018.
  14. Rochette E, Pascale D, Hourde C, Evrard B, Pereira B, Echaubard S, Merlin E. Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers. Mediators Inflamm. 2018: p. 9365745, 2018.




  1. Amirouche A, Jahnke VE, Lunde JA, Koulmann N, Freyssenet DG, Jasmin BJ. Muscle-specific microRNA-206 targets multiple components in dystrophic skeletal muscle representing beneficial adaptations. Am J Physiol Cell Physiol. 312(3): p. C209-C221, 2017.
  2. Benoit B, Meugnier E, Castelli M, Chanon S, Vieille-Marchiset A, Durand C, Bendridi N, Pesenti S, Monternier PA, Durieux AC, Freyssenet D, Rieusset J, Lefai E, Vidal H, Ruzzin J. Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. Nat Med. 23(8): p. 990-996, 2017.
  3. Chatel B, Bendahan D, Hourde C, Pellerin L, Lengacher S, Magistretti P, Le Fur Y, Vilmen C, Bernard M, Messonnier LA. Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice. FASEB J. 31(6): p. 2562-2575, 2017.
  4. Chatel B, Hourde C, Gondin J, Foure A, Le Fur Y, Vilmen C, Bernard M, Messonnier LA, Bendahan D. Impaired muscle force production and higher fatigability in a mouse model of sickle cell disease. Blood Cells Mol Dis. 63: p. 37-44, 2017.
  5. Chatel B, Messonnier LA, Bendahan D. Exacerbated in vivo metabolic changes suggestive of a spontaneous muscular vaso-occlusive crisis in exercising muscle of a sickle cell mouse. Blood Cells Mol Dis. 65: p. 56-59, 2017.
  6. Chatel B, Messonnier LA, Hourde C, Vilmen C, Bernard M, Bendahan D. Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice. J Appl Physiol (1985). 122(5): p. 1362-1369, 2017.
  7. Desgeorges MM, Devillard X, Toutain J, Castells J, Divoux D, Arnould DF, Haqq C, Bernaudin M, Durieux AC, Touzani O, Freyssenet DG. Pharmacological inhibition of myostatin improves skeletal muscle mass and function in a mouse model of stroke. Sci Rep. 7(1): p. 14000, 2017.
  8. Goron A, Lamarche F, Cunin V, Dubouchaud H, Hourde C, Noirez P, Corne C, Couturier K, Seve M, Fontaine E, Moinard C. Synergistic effects of citrulline supplementation and exercise on performance in male rats: evidence for implication of protein and energy metabolisms. Clin Sci (Lond). 131(8): p. 775-790, 2017.
  9. Mariot V, Joubert R, Hourde C, Feasson L, Hanna M, Muntoni F, Maisonobe T, Servais L, Bogni C, Le Panse R, Benvensite O, Stojkovic T, Machado PM, Voit T, Buj-Bello A, Dumonceaux J. Downregulation of myostatin pathway in neuromuscular diseases may explain challenges of anti-myostatin therapeutic approaches. Nat Commun. 8(1): p. 1859, 2017.
  10. Morel J, Gergele L, Domine A, Molliex S, Perrot JL, Labeille B, Costes F. The venous-arterial difference in CO2 should be interpreted with caution in case of respiratory alkalosis in healthy volunteers. J Clin Monit Comput. 31(4): p. 701-707, 2017.
  11. Morel J, Hargreaves I, Brealey D, Neergheen V, Backman JT, Lindig S, Blass M, Bauer M, McAuley DF, Singer M. Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis. Clin Sci (Lond). 131(8): p. 747-758, 2017.
  12. Morel J, Palao JC, Castells J, Desgeorges M, Busso T, Molliex S, Jahnke V, Del Carmine P, Gondin J, Arnould D, Durieux AC, Freyssenet D. Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice. Sci Rep. 7(1): p. 10866, 2017.
  13. Pauly M, Assense A, Rondon A, Thomas A, Dubouchaud H, Freyssenet D, Benoit H, Castells J, Flore P. High intensity aerobic exercise training improves chronic intermittent hypoxia-induced insulin resistance without basal autophagy modulation. Sci Rep. 7: p. 43663, 2017.
  14. Quiclet C, Dubouchaud H, Berthon P, Sanchez H, Vial G, Siti F, Fontaine E, Batandier C, Couturier K. Maternal exercise modifies body composition and energy substrates handling in male offspring fed a high-fat/high-sucrose diet. J Physiol. 595(23): p. 7049-7062, 2017.




  1. Gueugneau M, Coudy-Gandilhon C, Meunier B, Combaret L, Taillandier D, Polge C, Attaix D, Roche F, Feasson L, Barthelemy JC, Bechet D. Lower skeletal muscle capillarization in hypertensive elderly men. Exp Gerontol. 76: p. 80-8, 2016.
  2. Klionsky DJ, …, Freyssenet DG, …. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1): p. 1-222, 2016.
  3. Ling Y, Galusca B, Hager J, Feasson L, Valsesia A, Epelbaum J, Alexandre V, Wynn E, Dinet C, Palaghiu R, Peoc'h M, Boirie Y, Montaurier C, Estour B, Germain N. Rational and design of an overfeeding protocol in constitutional thinness: Understanding the physiology, metabolism and genetic background of resistance to weight gain. Ann Endocrinol (Paris). 77(5): p. 563-569, 2016.
  4. Morel J, Grand N, Axiotis G, Bouchet JB, Faure M, Auboyer C, Vola M, Molliex S. High veno-arterial carbon dioxide gradient is not predictive of worst outcome after an elective cardiac surgery: a retrospective cohort study. J Clin Monit Comput. 30(6): p. 783-789, 2016.
  5. Quiclet C, Siti F, Dubouchaud H, Vial G, Berthon P, Fontaine E, Batandier C, Couturier K. Short-term and long-term effects of submaximal maternal exercise on offspring glucose homeostasis and pancreatic function. Am J Physiol Endocrinol Metab. 311(2): p. E508-18, 2016.
  6. Theron L, Centeno D, Coudy-Gandilhon C, Pujos-Guillot E, Astruc T, Remond D, Barthelemy JC, Roche F, Feasson L, Hebraud M, Bechet D, Chambon C. A Proof of Concept to Bridge the Gap between Mass Spectrometry Imaging, Protein Identification and Relative Quantitation: MSI~LC-MS/MS-LF. Proteomes. 4(4), 2016.




  1. Costes F, Gosker H, Feasson L, Desgeorges M, Kelders M, Castells J, Schols A, Freyssenet D. Impaired exercise training-induced muscle fiber hypertrophy and Akt/mTOR pathway activation in hypoxemic patients with COPD. J Appl Physiol (1985). 118(8): p. 1040-9, 2015.
  2. Desgeorges MM, Devillard X, Toutain J, Divoux D, Castells J, Bernaudin M, Touzani O, Freyssenet DG. Molecular mechanisms of skeletal muscle atrophy in a mouse model of cerebral ischemia. Stroke. 46(6): p. 1673-80, 2015.
  3. Dupre-Aucouturier S, Castells J, Freyssenet D, Desplanches D. Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. J Appl Physiol (1985). 119(4): p. 342-51, 2015.
  4. Favier FB, Britto FA, Freyssenet DG, Bigard XA, Benoit H. HIF-1-driven skeletal muscle adaptations to chronic hypoxia: molecular insights into muscle physiology. Cell Mol Life Sci. 72(24): p. 4681-96, 2015.
  5. Gueugneau M, Coudy-Gandilhon C, Theron L, Meunier B, Barboiron C, Combaret L, Taillandier D, Polge C, Attaix D, Picard B, Verney J, Roche F, Feasson L, Barthelemy JC, Bechet D. Skeletal muscle lipid content and oxidative activity in relation to muscle fiber type in aging and metabolic syndrome. J Gerontol A Biol Sci Med Sci. 70(5): p. 566-76, 2015.
  6. Hill NE, Saeed S, Phadke R, Ellis MJ, Chambers D, Wilson DR, Castells J, Morel J, Freysennet DG, Brett SJ, Murphy KG, Singer M. Detailed characterization of a long-term rodent model of critical illness and recovery. Crit Care Med. 43(3): p. e84-96, 2015.
  7. Mariot V, Roche S, Hourde C, Portilho D, Sacconi S, Puppo F, Duguez S, Rameau P, Caruso N, Delezoide AL, Desnuelle C, Bessieres B, Collardeau S, Feasson L, Maisonobe T, Magdinier F, Helmbacher F, Butler-Browne G, Mouly V, Dumonceaux J. Correlation between low FAT1 expression and early affected muscle in facioscapulohumeral muscular dystrophy. Ann Neurol. 78(3): p. 387-400, 2015.
  8. Philippe AG, Py G, Favier FB, Sanchez AM, Bonnieu A, Busso T, Candau R. Modeling the responses to resistance training in an animal experiment study. Biomed Res Int. 2015: p. 914860, 2015.
  9. Ravelojaona M, Feasson L, Oyono-Enguelle S, Vincent L, Djoubairou B, Ewa'Sama Essoue C, Messonnier LA. Evidence for a profound remodeling of skeletal muscle and its microvasculature in sickle cell anemia. Am J Pathol. 185(5): p. 1448-56, 2015.




  1. Desgeorges MM, Freyssenet D, Chanon S, Castells J, Pugniere P, Bechet D, Peinnequin A, Devillard X, Defour A. Post-transcriptional regulation of autophagy in C2C12 myotubes following starvation and nutrient restoration. Int J Biochem Cell Biol. 54: p. 208-16, 2014.
  2. Eyenga P, Roussel D, Morel J, Rey B, Romestaing C, Teulier L, Sheu SS, Goudable J, Negrier C, Viale JP. Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria. J Physiol Biochem. 70(2): p. 285-96, 2014.
  3. Ferry A, Joanne P, Hadj-Said W, Vignaud A, Lilienbaum A, Hourde C, Medja F, Noirez P, Charbonnier F, Chatonnet A, Chevessier F, Nicole S, Agbulut O, Butler-Browne G. Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers. Neuromuscul Disord. 24(11): p. 960-72, 2014.
  4. Gallot YS, Durieux AC, Castells J, Desgeorges MM, Vernus B, Plantureux L, Remond D, Jahnke VE, Lefai E, Dardevet D, Nemoz G, Schaeffer L, Bonnieu A, Freyssenet DG. Myostatin gene inactivation prevents skeletal muscle wasting in cancer. Cancer Res. 74(24): p. 7344-56, 2014.
  5. Li Z, Parlakian A, Coletti D, Alonso-Martin S, Hourde C, Joanne P, Gao-Li J, Blanc J, Ferry A, Paulin D, Xue Z, Agbulut O. Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy. J Cell Sci. 127(Pt 21): p. 4589-601, 2014.
  6. Morel J, Singer M. Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target? Intensive Care Med Exp. 2(1): p. 9, 2014.
  7. Mouisel E, Relizani K, Mille-Hamard L, Denis R, Hourde C, Agbulut O, Patel K, Arandel L, Morales-Gonzalez S, Vignaud A, Garcia L, Ferry A, Luquet S, Billat V, Ventura-Clapier R, Schuelke M, Amthor H. Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 307(4): p. R444-54, 2014.
  8. Relizani K, Mouisel E, Giannesini B, Hourde C, Patel K, Morales Gonzalez S, Julich K, Vignaud A, Pietri-Rouxel F, Fortin D, Garcia L, Blot S, Ritvos O, Bendahan D, Ferry A, Ventura-Clapier R, Schuelke M, Amthor H. Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy. Mol Ther. 22(8): p. 1423-1433, 2014.