Damien FREYSSENET
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Dr. Damien Freyssenet is an exercise physiologist and biochemist, Professor at Jean Monnet University in Saint-Etienne. He graduated in 1995 at Saint Etienne Jean Monnet University on the topic of the influence of the energetic state on mitochondrial metabolism in skeletal muscle. Damien Freyssenet carried out a 2-year post-doctoral internship at York University (1995-1997, Toronto, Ontario, Canada) where he studied the regulatory mechanisms of mitochondrial biogenesis in skeletal striated muscle. Back in France, he successively held the position of Study Engineer (1997-2001, Jean Monnet Saint Etienne University), then Research Engineer (2001-2011, Jean Monnet Saint Etienne University), before being appointed University professor in 2011. Damien Freyssenet obtained his Habilitation à Diriger des Recherches in 1999. He is currently head of the Deconditioning Reconditioning of skeletal Muscle - Systemic Environment research team at the Laboratoire Interuniversitaire de Biologie de la Motricité. Damien Freyssenet's research activity focuses on the study of the mechanisms of muscle deconditioning under physiological (dry immersion) and pathological (cancer, myopathies of genetic origin and resuscitation) conditions, as well as on the development of strategies to limit/prevent this deconditioning. He has thus demonstrated the major role of myostatin in the skeletal muscle homeostasis in adulthood, which now allows him to develop reconditioning strategies based on the inhibition of myostatin. He also studies the impact of muscle deconditioning on the systemic environment and hepatic metabolism, with a particular interest in the role of glucocorticoids in the metabolic disturbance associated with cancer and sepsis. Finally, recent developments in his research activity leads him to study the effect of gender in skeletal muscle deconditioning associated with centro-nuclear myopathy. In November 2020, Damien Freyssenet had published 59 articles (cited> 5,000 times, H index = 28). He also directly supervised the thesis of 14 people and participated as an external reviewer for more than 60 PhD and Habilitation à Diriger des Recherches defenses. Damien Freyssenet is regularly financially supported by the Association Française contre les Myopathies, the Fondation ARC pour la Recherche sur le Cancer, the Ligue contre le Cancer, or the Centre National des Études Spatiales.
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Damien Freyssenet (damien.freyssenet @ univ-st-etienne.fr)
Phone: 04 77 42 14 77 Institution Université Jean Monnet (Saint-Etienne) Responsability Team Leader Team: [DeReM-SE] Position Professor
Publications |
1. Glutocorticoides and the hypothalamo-hypophyseal axis regulate muscle and liver metabolisms during cancer-associated cachexia. 2. Cancer-associated cachexia prevention by invalidation of the myostatin gene limits the development of tumors and increases life expectancy in two mouse models of cancer. 3. Activation of muscle proteolysis and increase of myostatin expression are early and transitional events of muscle deconditioning. 4. Mysotatin negatively regulates muscle muscle in adults by inhibiting muscle specific protein expression and protein synthesis. 5. Energetic state is a regulator of genetic expression in muscle tissue. | |
