Deconditioning Reconditioning of muscle and Systemic Environment
|
Research areas: Cancer Cachexia, Activity, Metabolism, Muscle Force, Myopathy, Inactivity, ICU-Acquired Muscle Weakness.
The main objective of our team is to understand the mechanisms of skeletal muscle deconditioning and to develop innovative and effective strategies to combat skeletal muscle deconditioning. Intrinsic (inside muscle fiber) and systemic regulatory mechanisms are explored to meet the following 4 objectives: ♦ to identify the cellular and molecular mechanisms at the origin of skeletal muscle deconditioning, ♦ to determine how the systemic environment contributes to skeletal muscle deconditioning, ♦ to determine how skeletal muscle deconditioning may contribute to the evolution of the pathological process, ♦ to develop strategies to prevent or limit the extent of muscle deconditioning.
The DeReM-SE team works on 4 pathologies associated with skeletal muscle deconditioning : digestive cancers (stomach, appendix, small intestine, colon) intensive care unit acquired myopathy, myopathies (FSHD, AD-CNM) non-alcoholic fatty liver disease with animal models and human patients. These studies associate the expertise of clinicians and scientists as part of a structured approach around the development of our systemic environment exploration platform in collaboration with the company CellMade
|
Team leader Members |
| |
| |
