• Biography

After obtaining her PhD in 2004, Anne Cécile was a post-doctoral fellow at the Institute of Anatomy of the University of Bern in Switzerland (2005-2007). During her PhD, she developed the technique of gene electrotransfer in skeletal striated muscle to study the molecular repercussions of the overexpression of protein(s) in muscle in rodents. During her post-doctorate in Switzerland, this technique was used to determine the involvement of the focal adhesion protein kinase (FAK) in skeletal striated muscle whose mechanical load was experimentally modified. In 2007, she joined a team at the Myology Research Centre of the Institute of Myology in Paris and initiated her work on centronuclear myopathy, in particular with the characterisation of the first mouse model of this genetic disease. In 2011, she obtained a position as a research engineer at the LIBM at the Jean Monnet University of Saint Etienne.
Anne Cécile's main research theme aims to better understand the physiopathological mechanisms leading to muscle atrophy (deconditioning) in order to set up strategies for restoring muscle mass and strength (reconditioning). This work is carried out on mouse models for centronuclear myopathy or colon cancer, in which different tissues are analysed on histological and molecular levels in order to determine a biological signature of the muscle damage as well as the potential systemic consequences. The strategy for restoring muscle function is mainly based on modulating the expression of myostatin, a growth factor specific to skeletal striated muscle. Anne Cécile is a member of the MyoNeuralp Alliance, a strategic cluster supported by the AFM-Telethon.
Since 2018, Anne Cécile has been President of the Loire Animal Experimentation Ethics Committee - Jean Monnet University. She is also a member of the scientific council of a local association providing financial support for medical research projects. By November 2020, Anne Cécile had published 23 articles and signed 60% of these publications in significant rank (1st or 2nd author).

Anne-Cécile Durieux (anne.durieux @ univ-st-etienne.fr)

Phone: 04 77 42 14 77

Institution

Université Jean Monnet

(Saint-Etienne)

Team: [DeReM-SE]

Position

Engineer